منابع مشابه
Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and carbamazepine dosing.
Human leukocyte antigen B (HLA-B) is a gene that encodes a cell surface protein involved in presenting antigens to the immune system. The variant allele HLA-B*15:02 is associated with an increased risk of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in response to carbamazepine treatment. We summarize evidence from the published literature supporting this association and ...
متن کاملI-33: Pharmacogenetics of Reproductive Medicine
Adverse drug reactions (ADRs) are a major problem in drug therapy and drug development. Inter-individual genetic differences can have significant roles in determining an individual’s susceptibility to ADRs. The rapid development of techniques in the area of genome analysis has put the scientific community in a power position and facilitated identification of new pharmacogenomic biomarkers that ...
متن کاملEffects of carbamazepine on male reproductive hormones
Background :Reproductive endocrine disorders and sexual dysfunction are common among men with epilepsy. We investigated sexual hormone serum levels among men with newly diagnosed epilepsy, before starting any antiepileptic drug (AED), and then after starting carbamazepine (CBZ), to determine the role and effects of epilepsy versus CBZ in creating reproductive endocrine disorders. Methods : ...
متن کاملNon-Recurrence of Carbamazepine Induced Vitiligo after Rechallenge with Carbamazepine
OBJECTIVE Vitiligo is a rare side effect of carbamazepine whose exact mechanism is unknown. The aim of this report is to describe a single case of vitiligo induced by carbamazepine. METHODS The case was a patient with Bipolar I disorder whose medications were changed from valproate to carbamazepine and who developed vitiligo after a short while. We followed the case for about four years when ...
متن کاملExperimental Pharmacogenetics
Furthermore, Dr. Moulder is able to make the reader realize that the problem has considerable theoretical and practical value and is not just an exercise in semantics. It is a stimulating book. Investigators in a wide variety of fields will find this short volume an extremely useful reference book. The purpose of the monograph was to bring together the known biochemical and structural inherited...
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ژورنال
عنوان ژورنال: Epilepsy and paroxysmal conditions
سال: 2020
ISSN: 2311-4088,2077-8333
DOI: 10.17749/2077-8333.2019.11.4.364-378